Wayfaring+Tree+–+Viburnum+Lantana

=Wayfaring Tree – Viburnum Lantana =  //**Family: Caprifoliaceae**// 


 * 1 Part Used:
 * 2 Abstracts of Published Research on Wayfaring Tree – Viburnum Lantana
 * 3 Oligo-elements:
 * 4 Vitamins and Minerals:
 * 5 Phytochemical Constituents:
 * 6 Plant Stem Cell Therapy Indications
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.1 Pulmonary System:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.2 Infectious Disease – Immunology:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.3 Musculoskeletal System:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.4 Dental
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.5 Neurological
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.6 Gi-Digestive Hepatology:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.7 Psychiatry
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.8 Cardiovascular Disease
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.9 Allergy:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.10 Dermatology:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.11 Endocrine System:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.12 Infectious Diseases:
 * <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; line-height: 1.5em; list-style-image: none; list-style-type: none; margin-bottom: 0px; margin-left: 2em; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; text-align: left; text-decoration: none;">6.13 OB GYN/ Reproductive System:

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Part Used: ** <span style="border-bottom-color: white; border-bottom-style: solid; border-bottom-width: 0.8em; border-left-color: white; border-left-style: solid; border-left-width: 1.4em; border-right-color: white; border-right-style: solid; border-right-width: 0px; border-top-color: white; border-top-style: solid; border-top-width: 0.5em; clear: right; display: block; float: right; margin-bottom: 0.5em; width: auto;"><span style="background-color: #f9f9f9; border: 1px solid #cccccc; display: block; font-size: 12px; overflow-x: hidden; overflow-y: hidden; padding: 3px !important; text-align: center; width: 136px;">

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Buds

NOTE: //These indications are only for use with embryonic plant stem cell tissues. Adult plants do not have the same constituents, actions or applications in most cases.//

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">The //Viburnum lantana// is a medium to large, deciduous shrub that is native to Europe and western Asia. This multistemmed, spreading shrub grows 10 to 15 feet high and produces a somewhat rounded outline. Its thick, green leaves are opposite, simple oval to lanceolate, and are 2 to 5 inches long with finely serrated margins and white, silky-haired undersides. Clusters of creamy white, 5 inch, flat-topped flowers canvas the shrub from May to June. Berries are green, flushed with red, then turn black in early fall, often showing all three colors at once. The fruit can be eaten either raw or cooked. Common uses of this tree include rootstock and twine.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Abstracts of Published Research on Wayfaring Tree – Viburnum Lantana: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">1. <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; color: #002bb8; text-decoration: none;">Int J Food Sci Nutr. 2008 May;59(3):175-80. Antioxidant properties of Viburnum opulus and Viburnum lantana growing in Turkey .//Altun ML, Citoğlu GS, Yilmaz BS, Coban T.// <span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">2. Biochem Pharmacol. 1986 Jan 15;35(2):257-62. Inhibition of human platelet cyclic AMP phosphodiesterase and of platelet aggregation by a hemisynthetic flavonoid, amentoflavone hexaacetate.//Beretz A, Briançon-Scheid F, Stierlé A, Corre G, Anton R, Cazenave JP.//

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Oligo-elements: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Cr, Fe, K, Mg, Mn, P, Se, Si, Ti, Zn.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Vitamins and Minerals: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Calcium.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Phytochemical Constituents: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Acetic-Acid, Alpha-Amyrin, //**Amentoflavone**//, //**Anthocyanins**// 42%, Apigenin, Arbutin, Astragalin, **Auxins** (**IAA**), Beta-Amyrin, Betulalbuside A, Beta-Sitosterol, //**Boswellic acid**//, **Brassinosteroids (BR)**, Chlorogenic-Acid, //**Chrysoeriol 7-O-b-glucosides, Chrysoeriol (luteolin 3'-methyl ether)**//, Cinnamic-Acid, Citric-Acid, Cyanidin 3-O-vicianoside, Cytokinins (CK), //**Dihydropenstemide**//, Epicatechin, **Gibberellins (GA)**,**Jasmonic acid (JA)**, **Kaempferol, Lantanoside,** Malic-Acid, **Meristems plant stem cells (PSC)**, Pectin, Quercetin //**Rosarin**//, **Salicylic acid (SA)** specific **Salicin**, Scopoletin, and Sculetin, Tannin, Ursolic-Acid, //Valerianic acid//, //**Viburnine, Vicianose, Vibsanin O**//.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">A new monocyclic C10 iridoid glucoside //**Lantanoside**// was isolated from the buds of Viburnum lantana, together with the two known glucosides,//**dihydropenstemide**// and //**betulalbuside A.**//

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">The structure of the new compound, lantanoside, was established from extensive 1H and 13C NMR, 1D and 2D homo-and heteronuclear correlation experiments.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">The isolation of //**six iridoid glucosides**// (liver protecting qualities): the novel 10,2'-diacetylpatrinoside, 1, and the known 2'-acetyldihydropenstemide, 2'-trans- p-coumaroyl-dihydropenstemide, 2'-acetylpatrinoside, decapetaloside, and patrinoside. In addition,**amentoflavone** and rosarin were also isolated. The inhibitory effect of phenylpropanoid glycosides and iridoid glucosides on free radical production.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">This altered level of cytokines after amentoflavone treatment was also accompanied by enhanced natural killer cell antibody—dependent cellular cytotoxicity. The study reveals that amentoflavone treatment could alter proinflammatory cytokine production and could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor— B, and other transcription factors such as c-fos, activated transcription factor—2, and cyclic adenosine monophosphate response element—binding protein in B16F-10 melanoma cells.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">**1. References: Integrative Cancer Therapies, Vol. 6, No. 2, 185-197 (2007)** DOI: 10.1177/1534735407302345 © 2007 SAGE Publications

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Amentoflavone inhibits the binding of flumazenil to the benzodiazepine binding site of the GABA A -receptor (IC (50) = 14.9 nM).

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">**2. References: Dept. of Research and Div. of Clinical Pharmacology and Toxicology, University Hospital, Basel, Switzerland.**
 * ~ Alpha Amyrin ||~ Beta Amyrin ||
 * Prevent I kappaB alpha (which its function is being an Inhibitor protein) prevent degradation of cartilage and synovial. || A precursor or (analogue) of Boswellic acid and boswellic acid is anti glycosaminoglycans GAGase properties prevent degradation of cartilage. ||
 * COX2 inhibitor<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Strong anti-inflammatory activity. || An orally Active Opioid Analgesic. ||
 * Protein kinase A PKA inhibitor at 8 micromolar. || COX2 inhibitor. ||
 * Protease inhibitor returned the increases in serum hyaluronate and blood granulocytes to non-arthritic levels and corrected the moderate anemia of adjuvant arthritis. Returned the increases in serum hyaluronate and blood granulocytes to non-arthritic levels and corrected the moderate anemia of adjuvant arthritis. Proximal foot interphalangeal joints showed reduced synovial proliferation and invasion of joints and reduced leucocyte infiltration of bone marrow. prevented or reduced bone (subchondral or cortical) and cartilage (articular) destruction. Helps in maintaining joint mobility || Chymotrypsin-specific inhibitor (MCoCI). The effects of MCoCI on different types of cells of the immune system, including splenocytes, splenic lymphocytes, neutrophils, bone marrow cells and macrophages, immuno-enhancing and antiinflammatory effects. also suppress the formation of hydrogen peroxide in neutrophils and macrophages. ||

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: #aaaaaa; border-bottom-style: solid; border-bottom-width: 1px; color: black; font-size: 19px; font-weight: normal; margin-bottom: 0.6em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;"> Plant Stem Cell Therapy Indications: <span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">//Most Fascinating Plant//

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Pulmonary System: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">'P' //**Pulmonary Detoxifier, Asthma**//, Exercise Induced Asthma, Pulmonary neuro-vegetative regulatory action, Bronchospasm, Dyspnea, Asthmatic, Inhibits the bronchospasm cough. The //**iridoids play a significant role**// in the biological activity being spasmolytic, sedative, and anti-asthmatic. //**Chrysoeriol (luteolin 3'-methyl ether)**// is a bioactive flavonoid known for antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities. Anti-Asthmatic by //**inhibiting 5-lipoxygenase**// and //**inhibits leukotriene formation**//. Indicates that the bronchodilator, antispasmodic and blood pressure lowering effects of this luteolin metabolite derivative are mediated predominantly through K (ATP) channel activation with the selective //**bronchodilator effect**//. //**Luteolin**// therapeutic //**modulation of allergic airways disease with leukotriene receptor antagonists**//. Many studies have shown a sound mechanistic basis for the wide medicinal use of Viburnum lantana buds, with the therapeutic potential for //**congestive respiratory ailments. COPD**//. //**Scopoletin**// and Sculetin have //**anti-inflammatory**// activity and can be used to treat bronchial illnesses and //**asthma**// by being an //**environmental histamine inhibitor**//. Help reduce the severity of asthmatic symptoms by also boosting the immune system while strengthening the cellular structure of the bronchial tubes.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Chrysoeriol (luteolin 3'-methyl ether) and Beta Amyrin which is a precursor of Boswellic acid are all lipoxygenase inhibitors. Which are phytochemicals which slows down or stops the action of the lipoxygenase enzyme. More precisely, the term is almost always used to describe an inhibitor of the arachidonate 5-lipoxygenase enzyme, thus inhibits leukotrienes. Leukotrienes are fatty molecules of the immune system that contribute to inflammation in asthma and bronchitis. Leukotriene antagonists are used to treat asthma and bronchitis. Their production usually accompanies the production of histamine.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">**Examples Leukotriene antagonists include:**

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">• Azelastine: is an antihistamine. • Diethylcarbamazine: is an anthelmintic drug that does not resemble other antiparasitic compounds. For pulmonary eosinophilia. • Zileuton: s an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. Zileuton is used for the maintenance treatment of asthma. Related compounds include montelukast (Singulair) and zafirlukast (Accolate). These two compounds are leukotriene receptor antagonists which block the action of specific leukotrienes, while zileuton inhibits leukotriene formation.

When it comes to //**“The Pathophysiology Intervention of Allergies”**//, you must attend to the causes of which there is only three. One, adrenal dysfunction (hyper or hypo) in their role of producing cortico steroids which produces natural antihistamines, Secondly, the liver may need detoxification. Last but not least the immune system could either be: immune suppressed, auto immune or hyper immune. Once you have evaluated and diagnosed the cause or causes of such allergies and that you have designed a //**“Custom Made Biotherapeutic Program”**// aimed at targeting the root of the problem(s), then you can effectively correct and relieve the suffering of long standing allergies permanently.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Infectious Disease – Immunology: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">P Studies have shown that //**Lantanoside**// to be very effective against //**Mycobacterium tuberculosis**//, strain H (37) Rv. These compounds exhibited 98% inhibition, respectively at 6.25 microg mL (-1) concentration. (Begum S; Wahab A; Siddiqui B S). Natural product research 2008; 22(6):467-70. **Amentoflavone** enhanced //**natural killer cell antibody—dependent cellular cytotoxicity. Scopoletin**// and //**Sculetin**//(antioxidant phytoalexin) has //**bacteriostatic activity**// against various species of bacteria, including Escherichia coli, Helicobacter pylori, Staphylococcus aureus, Streptococcus sp., Klebsiella pneumoniae and Pseudomonas aeruginosa.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Musculoskeletal System: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">**P** //**Beta-Amyrin**// an orally //**Active Opioid Analgesic**//. //**Alpha-amyrin**// //**COX2**// //**inhibitor**// antiinflammatory, //**Prostaglandin Inhibitor**//, **Ankylosing Peri-Arthritis**. **Antinociceptive** //**orofacial nerve pain from alpha-beta amyrin**//. **Posology**: For these conditions you will need much higher dosage of 10 to 30 drops 3 to 4 x a day. Or you can give 10 drops Q2hrs.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">//**Alpha-amyrin palmitate**// returned the //**increases**// in //**serum hyaluronate**// and //**blood granulocytes**// to //**non-arthritic**// levels and corrected the moderate anemia of adjuvant arthritis. //**Alpha amyrin**// //**helps in maintaining joint mobility.**// Histological examinations of the second and third proximal foot //**interphalangeal joints**// showed //**reduced synovial proliferation**// and //**invasion of joints**// and //**reduced leucocyte infiltration of bone marrow**// in alpha-amyrin palmitate-treated rats. In addition, this phytochemical //**prevented**// or //**reduced bone (subchondral or cortical)**//and //**cartilage**// (articular) //**destruction**// in arthritic rats. The results suggest that alpha-amyrin palmitate is antiarthritic in the adjuvant model of arthritis in rats. //**Beta-Amyrin**// precursor of //**Boswellic acid is a strong 5-lipoxigenase inhibitor**// and causes //**significant depression**// of//**sulphated glycosaminoglycan**// GAGase //**synthesis in cartilage**// and also has //**anti elastase**// properties. //**Lupeol**// is has efficient an//**antiinflammatory**// as Indomethacin.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">**References: Effect of alpha-amyrin palmitate on adjuvant arthritis. Drugs Exp Clin Res. 1994 ;20 (1):1-5 7924889 (P,S,E,B) G Kweifio-Okai, D Bird, P Eu, A R Carroll, R Ambrose, B Field Department of Anatomy and Physiology, Royal Melbourne Institute of Technology, Bundoora, Australia.**

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Dental: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">'P' //Alpha// and //Beta// //**Amyrin**// have demonstrated effectiveness in //**Gingivitis**// and preventing //**chronic periodontitis-associated bone loss.**//

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Neurological: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">'P' //Beta// //Amyrin// an orally //Active Opioid Analgesic//. //Alpha// and //Beta// //**Amyrin**// are considered they have //**broad-spectrum analgesic**//. //Alpha-Amyrin//is a //**precursor of Ursolic acid**// that is obtained by converting the CH3 in 28 to COOH. //Beta Amyrin// is a precursor of //**Boswellic acid**// that is obtained by converting the CH3 in 24 to COOH. Cranio facial pain. Associated conditions include //**local inflammatory**// and //**neoplastic disorders**// and //**neuralgic syndromes**// involving the trigeminal TMJ, and //**glossopharyngeal nerves**//. //**Exhibited stronger antinociceptive activity**// than aspirin at a 200 mg/kg dose. Anti-inflammatory activity compared to indomethacin.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Gi-Digestive Hepatology: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">'P' Hepatoprotective from //Alpha// and //Beta// //**Amyrin**// and //**Rosarin**// **antagonist** of **benzodiazepine receptors**. Will //**detoxify**// the //**liver**// from //**drug toxicity**// especially //**benzodiazepine**// //**acetaminophen-induced liver injury**// and all //**narcotics**//. //**Amentoflavone benzodiazepine antagonist**//, used as an antidote in the treatment of //**benzodiazepine overdose**// or //**drug addiction**// to //**Valium, Ambien**// and //**Xanax**// for any of these conditions the posology must be given with frequency at a dosage of for the purpose 10 drops q2hrs six times per day.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">The serum AST (SGPT), ALT (SGOT), ALP (Alkaline Phosphatase) and bilirubin levels significantly reduced by the use of this plant. Strong antioxidant on the 2, 2-diphenyl-1-picrylhydrazyl DPPH radical scavenging activity. Also it normalized the level of antiradical hepatic activity and had a pronounced glutathione-saving effect, which is preconditioned by the biological activity of oligomeric //**anthocyanidins**// (affinity for free radicals). The preparation can be used in prevention and treatment of toxic hepatic lesions.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">//Lupeol// to //**regenerate**// the “//Holy Trinity Antioxidant Enzymes//” being SOD, //Catalase// and //Glutathione peroxidase//. Lupeol; Lupeol linoleate; Antihepatotoxic activity. //**Sculetin**// which //**binds**// to and //**activates**// the //**hepatic nuclear receptor**// constitutive androstane (the hydrocarbon nucleus, C19H32, from which androgens are derived) receptor CAR and its target genes, //**leading**// to //**increased**// //**clearance**// of //**bilirubin**//. CAR functions differently from other steroid receptors and its activity is still being elucidated. It is known to act in concert with the pregnane (indirectly, a parent of progesterone) X receptor PXR to detoxify //**xenobiotics**// are both nuclear receptors whose primary function is to sense the presence of foreign toxic substances and in response //**up regulate**// the //**expression**// of //**proteins**// involved in the //**detoxification**// and //**clearance**// of these //**substance**// from the body.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Psychiatry: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">'P' //Natural Antihistamine// Studies reveal and suggest that //Beta-Amyrin// //**palmitate**// releases norepinephrine from newly synthesized pools, and thus, it might activate noradrenergic activity. A possible mechanism of //**antidepressant**// activity of beta-amyrin. //**Sedative**// and //**anxiolytic effects**//. Compared to the //**antidepressant**// drugs, mianserin and imipramine. The //**adaptogenic**//, cardiopulmonary protective, and central nervous system activities of the phytochemicals //**Cyanidin 3-O-vicianoside**// and //**Rosarin**// have been attributed primarily to its ability to influence levels and activity of //**monoamines**// and //**opioid peptides**// such as //**beta-endorphins. Scopoletin**// regulates the //**hormone serotonin**//, which helps to reduce anxiety and depression.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Cardiovascular Disease: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Antioxidant and Anti-inflammatory activities, //**Chrysoeriol 7-O-b-glucosides**// may be used for the '//**prevention'**// and //**treatment**// of vascular diseases and during //**restenosis**// after //**coronary angioplasty**//. Chrysoeriol has demonstrated and proven to significantly inhibit //**platelet-derived growth factor**// (PDGF)-BB and its effect on the //**proliferation**// of //**human aortic smooth muscle cells**// (HASMC). Also blocked PDGF-stimulated dissociation of actin filament and inhibited PDGF beta-receptor (Rβ) phosphorylation. As a result, the downstream signal transduction pathways of PDGF-Rβ, including ERK1/2, p38, and Akt phosphorylation, were also inhibited by chrysoeriol in the same pattern. Inhibits effect on AP-1 activation by chrysoeriol may be associated with its potent nitric oxide NO blocking and anti-inflammatory effects. The //**adaptogenic**//, cardiopulmonary protective and central nervous system activities of the phytochemicals //**Cyanidin 3-O-vicianoside**//. Lupeol antioxidant and antiinflammatory also helps to decrease the level of lipid peroxides. //**Scopoletin**// and //**Sculetin**// of //**bipolar – biphasic actions**//, seems to regulate the **blood pressure**: when the blood pressure is high, //**Scopoletin**// and //**Sculetin**// helps to lower it and when it is too low it can help raise it.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Allergy: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">'A' Allergies, Spasmodic Rhinitis.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Dermatology: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Psoric Diathesis in homeopathy, Eczema that has a foul odor, Dermatomyositis. Known to inhibit body odors.Lantanoside is effective in healing excision wounds in the experimental animal and could be evaluated as a therapeutic agent in tissue repair processes associated with skin injuries. Treatment of the wounds with extract enhanced significantly the rate of wound contraction (98%), synthesis of collagen and decreased mean wound healing time.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">References: A preclinical study done by; B. Shivananda Nayak 1 *, S. Sivachandra Raju 2, Mathew Eversley 2, Adash Ramsubhag 3 <span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">1Department of Preclinical Sciences, Biochemistry Unit, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad. <span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">2Department of Para clinical Sciences, Faculty of Medical Sciences, The University of the West Indies. <span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">3Department of Life Sciences, Faculty of Science and Agriculture, The University of the West Indies, St Augustine, Trinidad.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">Most of the skin cell types have neurotransmitters receptors; the skin itself produces neurotransmitters. β-endorphins are neuropeptides, composed of 35 amino acids, with neurotransmitter action. Rosarin, Alpha-Beta Amyrins and Amentoflavone all are Adaptogens which influences β-endorphins which are known agonists to all of the opioid receptors (they bind all opioid receptors specifically), although they have greater affinity for μ, δ and ε opioid receptors. The proopiomelanocortin (POMC) gene codifies for the precursor to β-endorphins and other neurotransmitters. It has been found that keratinocytes and fibroblasts express this gene and the necessary molecules to synthesize its derived substances (melanocyte-stimulating hormones MSH, adrenocorticotropic hormone ACTH, β-endorphin and β-lipotropin). By using specific biochemical techniques, it has been shown that the β-endorphin system and the μ opioid receptor are present in human melanocytes and keratinocytes, where they play a role in skin pigmentation (Slominski et al 2000); μ opioid receptors have also been identified in cells composing the outer root sheath of hair follicles and in peripheral epithelial cells of sebaceous glands. Such interactions play a key role in skin homeostasis, as well as in skin disorders (Pincelli et al. 2004). Liquid emollients enriched in the characteristic triterpene esters such as lupeol and amyrin cinnamates. The beneficial effects in skin care applications from these phytochemicals includes; anti-irritant and antiinflammatory biological actions and sunscreen protection. Ursolic acid has anti elastase activity, and like cholesterol, modulates the membrane fluidity. It prevents UV-B irradiation damages to the skin through prevention of lipid peroxidation and prostaglandin Inhibitor PGE2. Phytosterols that are present in these buds have a similar structure to cholesterol and play the same role by interacting with lamellar lipid layers and increasing their stability. Phytosterols topical dermatological application increases moisturization. Lupeol which regenerate the antioxidant enzymes will also result in a lowered destruction of structural molecules like collagenase.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Endocrine System: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">'A' Hyperthyroidism, Basedow Disease, Axis diencephalic thyroid.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** Infectious Diseases: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">P Amentoflavone antiviral significant activity against Influenza A and B viruses.

 <span style="background-attachment: scroll; background-clip: initial; background-color: transparent; background-image: none; background-origin: initial; background-position: 0% 0%; background-repeat: repeat repeat; border-bottom-color: initial; border-bottom-style: none; border-bottom-width: medium; color: black; font-size: 17px; margin-bottom: 0.3em; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0.17em; padding-top: 0.5em;">** OB GYN/ Reproductive System: **

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">A Uterine spasmolytic and calms and alleviate uterine pain in menstrual disorders (dysmenorrhea and amenorrhea). But not superior to cramp bark for ovarian pain.

<span style="line-height: 1.5em; margin-bottom: 0.5em; margin-left: 0px; margin-right: 0px; margin-top: 0.4em;">**Oncology Investigational :** Inhibits human platelet cAMP phosphodiesterase. Antimetastatic activity of amentoflavone. Amentoflavone treatment significantly reduced tumor nodule formation accompanied by reduced lung collagen hydroxyproline, hexosamine, and uronic acid levels. This altered level of cytokines after amentoflavone treatment was also accompanied by enhanced natural killer cell antibody—dependent cellular cytotoxicity. Antimetastatic activity of amentoflavone using B16F-10 melanoma—induced experimental lung metastasis in C57BL/6 mice. Vibsanin O (bicyclic diterpenoid): a novel diterpenoid Antimalaria; Radical scavenging activity; Antineoplastic-Agents; Cytotoxicity against human nasopharyngeal carcinoma (HONE-1) tumor cells and human gastric cancer (NUGC-3) cells.